Silent seizures refer to epileptic activity occurs when Alzheimer's disease (AD) patients are sleeping. This can be resolved after they take levetiracetam, the anti-epileptic medicine. In the research on a woman with this sympton, her cognition declined continuously. Levetiracetam may have helped to slowed down this process, and after having missed several consecutive doses of levetiracetam, the woman reported being confused a year later.
Researchers at Massachusetts General Hospital in Boston was working on this case. Andrew Cole, team leader, supposed that silent seisures may account for memory loss, anxiety, and even accelerated neurodegeneration in AD patients. They confirmed that therapy with levetiracetam not only relieved symptoms, but also slowed disease progression. Though using higher doses of levetiracetam, Cole added that levetiracetam treatment in low doses, besides ameliorating hyperactivity and improving cognition as demonstrated by early clinical studies, might have the desired effect on neuronal overactivity in the medial temporal regions with very few side effects.